New paper in Bioinformatics


SYNPHONI: scale-free & phylogeny-aware reconstruction of synteny conservation & transformation across animal genomes.

Robert NSM, Sarigol F, Zieger E & Simakov O. 2022.  Bioinformatics btac695. doi: 10.1093/bioinformatics/btac695 (Q1). Link. Published online 21 October 2022

Current approaches detect conserved genomic order either at chromosomal (macro-synteny) or at subchromosomal scales (microsynteny). The latter generally requires collinearity and hard thresholds on syntenic region size, thus excluding a major proportion of syntenies with recent expansions or minor rearrangements. “SYNPHONI” bridges the gap between micro- and macro-synteny detection, providing detailed information on both synteny conservation and transformation throughout the evolutionary history of animal genomes.

Availability and Implementation:
Source code is freely available 'here' {{}}, implemented in Python3.9.

Supplementary information:
Supplementary data are available at Bioinformatics online.